Coagulation Clotting Mechanisms - MCAT Content

Coagulation Clotting Mechanisms - MCAT Content coagulation cascade Triggered by the exposure of tissue factor in the damaged blood vessel wall to the circulating factor VII Final Common Pathway The Coagulation Cascade coagulation cascade coagulation cascade Excess circulating thrombin results from the excess activation of the coagulation cascade The excess thrombin cleaves fibrinogen

coagulation cascade The levels of activated Protein C and ProteinS increase at the site of coagulation This increase

coagulation cascade KEY WORDS: anticoagulants, blood coagulation, haemostasis, thromboplastin , thrombosis THE COAGULATION 'CASCADE' The coagulation cascade as it Key Points · Coagulation is a complex physiologic process balancing prothrombotic and antithrombotic factors · Improved understanding of the